Pentatricopeptide Repeat Domain-Containing Proteins in Mammals and Budding Yeast
نویسندگان
چکیده
منابع مشابه
Pentatricopeptide repeat proteins
Mitochondria and chloroplasts host genomes inherited from their bacterial ancestors. Their biogenesis thus requires fully functional gene expression machineries. RNA metabolism in organ-elles is particular and has attracted considerable attention since it combines prokaryotic features with unique traits that evolved in their eukaryotic host cell. For a long time, most of the molecular factors g...
متن کاملChloroplast RNA-binding and pentatricopeptide repeat proteins.
Chloroplast gene expression is mainly regulated at the post-transcriptional level by numerous nuclear-encoded RNA-binding protein factors. In the present study, we focus on two RNA-binding proteins: cpRNP (chloroplast ribonucleoprotein) and PPR (pentatricopeptide repeat) protein. These are suggested to be major contributors to chloroplast RNA metabolism. Tobacco cpRNPs are composed of five diff...
متن کاملPPR (pentatricopeptide repeat) proteins in mammals: important aids to mitochondrial gene expression.
Genes encoding PPR (pentatricopeptide repeat)-containing proteins constitute one of the largest gene families in plants. The majority of these proteins are predicted to target organelles and to bind to RNA. Strikingly, there is a dearth of these proteins in mammals, although genomic searches reveal six candidates, all of which are also predicted to target the mitochondrion. Two of these protein...
متن کاملChloroplast RNA editing by pentatricopeptide repeat proteins.
Pentatricopeptide repeat (PPR) proteins function in multiple processes in mRNA maturation in plastids and mitochondria (reviewed in Schmitz-Linneweber and Small, 2008). RNA maturation in chloroplasts is complex, and PPR proteins act in cisand trans-splicing, translation, RNA cleavage, RNA stabilization, and RNA editing. This large protein family, with 450 members in Arabidopsis, is characterize...
متن کاملPentatricopeptide repeat proteins in Trypanosoma brucei function in mitochondrial ribosomes.
The pentatricopeptide repeat (PPR), a degenerate 35-amino-acid motif, defines a novel eukaryotic protein family. Plants have 400 to 500 distinct PPR proteins, whereas other eukaryotes generally have fewer than 5. The few PPR proteins that have been studied have roles in organellar gene expression, probably via direct interaction with RNA. Here we show that the parasitic protozoan Trypanosoma br...
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ژورنال
عنوان ژورنال: Cell & Developmental Biology
سال: 2012
ISSN: 2168-9296
DOI: 10.4172/2168-9296.1000e108